"I love applying my skills and experience to create new solutions and explore new dimensions within biomedical optics and biophysics."
"I aim for perfection in the development of new tools for functional imaging, exploiting switchable transitions in fluorescent proteins and organic dyes."
"I strive to develop novel and paradigm-shifting techniques by exploring new ways to harness smart illuminations and optical transitions in order to address contemporary challenges in biophysics and molecular biology."
The method is based on long-lived reversible molecular transitions of switchable fluorescent proteins to resolve the relatively slow rotational diffusivity of large complexes. In the publication we probe the rotational mobility of several molecular complexes in living cells, including chromatin, the retroviral Gag lattice, and activity-regulated cytoskeleton-associated protein oligomers. The ability to probe arbitrarily large structures, make it generally applicable to the entire human proteome.